MersV1, Main, Exploration, bibRecord, 001E88

The novel MER transposon-derived miRNAs in human genome.

Identifieur interne : 001E88 ( Main/Exploration ); précédent : 001E87; suivant : 001E89

The novel MER transposon-derived miRNAs in human genome.

Auteurs : Kung Ahn [Corée du Sud] ; Jeong-An Gim ; Hong-Seok Ha ; Kyudong Han ; Heui-Soo Kim

Source :

Gene [ 1879-0038 ] ; 2013.

RBID : pubmed:22926102

Descripteurs français

KwdFr :
- ADN intergénique (génétique), Cellules HEK293, Cellules HeLa, Chromosomes humains de la paire 17 (génétique), Chromosomes humains de la paire 8 (génétique), Génome humain (physiologie), Humains, Séquences répétées inversées (physiologie), microARN (génétique), Éléments transposables d'ADN (physiologie).
MESH :
- génétique : ADN intergénique, Chromosomes humains de la paire 17, Chromosomes humains de la paire 8, microARN.
- physiologie : Génome humain, Séquences répétées inversées, Éléments transposables d'ADN.
- Cellules HEK293, Cellules HeLa, Humains.

English descriptors

KwdEn :
- Chromosomes, Human, Pair 17 (genetics), Chromosomes, Human, Pair 8 (genetics), DNA Transposable Elements (physiology), DNA, Intergenic (genetics), Genome, Human (physiology), HEK293 Cells, HeLa Cells, Humans, Inverted Repeat Sequences (physiology), MicroRNAs (genetics).
MESH :
- chemical , genetics : DNA, Intergenic, MicroRNAs.
- chemical , physiology : DNA Transposable Elements.
- genetics : Chromosomes, Human, Pair 17, Chromosomes, Human, Pair 8.
- physiology : Genome, Human, Inverted Repeat Sequences.
- HEK293 Cells, HeLa Cells, Humans.

Abstract

MicroRNAs (miRNAs) are small RNA molecules (~20-30 nucleotides) that generally act in gene silencing and translational repression through the RNA interference pathway. They generally originate from intergenic genomic regions, but some are found in genomic regions that have been characterized such as introns, exons, and transposable elements (TE). To identify the miRNAs that are derived from palindromic MERs, we analyzed MER paralogs in human genome. The structures of the palindromic MERs were similar to the hairpin structure of miRNA in humans. Three miRNAs derived from MER96 located on chromosome 3, and MER91C paralogs located on chromosome 8 and chromosome 17 were identified in HeLa, HCT116, and HEK293 cell lines. The interactions between these MER-derived miRNAs and AGO1, AGO2, and AGO3 proteins were validated by immunoprecipitation assays. The data suggest that miRNAs derived from transposable elements could widely affect various target genes in the human genome.

DOI: 10.1016/j.gene.2012.08.028
PubMed: 22926102

Affiliations:

Corée du Sud

Le document en format XML

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<term>Genome, Human (physiology)</term>
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<front><div type="abstract" xml:lang="en">MicroRNAs (miRNAs) are small RNA molecules (~20-30 nucleotides) that generally act in gene silencing and translational repression through the RNA interference pathway. They generally originate from intergenic genomic regions, but some are found in genomic regions that have been characterized such as introns, exons, and transposable elements (TE). To identify the miRNAs that are derived from palindromic MERs, we analyzed MER paralogs in human genome. The structures of the palindromic MERs were similar to the hairpin structure of miRNA in humans. Three miRNAs derived from MER96 located on chromosome 3, and MER91C paralogs located on chromosome 8 and chromosome 17 were identified in HeLa, HCT116, and HEK293 cell lines. The interactions between these MER-derived miRNAs and AGO1, AGO2, and AGO3 proteins were validated by immunoprecipitation assays. The data suggest that miRNAs derived from transposable elements could widely affect various target genes in the human genome.</div>
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Serveur d'exploration MERS

The novel MER transposon-derived miRNAs in human genome.

The novel MER transposon-derived miRNAs in human genome.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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